Table 3.
Longitudinal Association Between Baseline Clinical Cholesterol Cutoffs and Cognition.
| Cholesterol Coefficient |
Cholesterol × Time Examinations 1–3 |
Cholesterol × Time Examinations 4–6 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood Cholesterol (mg/dL) per SD Increase | B | p Value | B | p Value | B | p Value | ||||||
| TMT-A | ||||||||||||
| Total cholesterol | ||||||||||||
| 200–239 vs <200 | −1.037 | .674 | 0.808 | .373 | −0.382 | .470 | ||||||
| >240 vs <200 | −0.475 | .848 | 0.234 | .805 | −0.046 | .925 | ||||||
| TMT-B | ||||||||||||
| Total cholesterol | ||||||||||||
| 200–239 vs <200 | −1.910 | .480 | 1.192 | .305 | 0.444 | .756 | ||||||
| >240 vs <200 | −2.017 | .448 | 0.661 | .473 | 0.062 | .928 | ||||||
| Pegboard | ||||||||||||
| Total cholesterol | ||||||||||||
| 200–239 vs <200 | −1.260 | .146 | 0.273 | .340 | ||||||||
| >240 vs <200 | −1.960 | .023 | 0.081 | .774 | ||||||||
| HVLT-R, Immediate Recall | ||||||||||||
| Total cholesterol | ||||||||||||
| 200–239 vs <200 | −0.161 | .910 | 0.475 | .308 | 0.096 | .698 | ||||||
| >240 vs <200 | −0.305 | .827 | 0.295 | .532 | 0.147 | .544 | ||||||
| HVLT-R, Delayed Recall | ||||||||||||
| Total cholesterol | ||||||||||||
| 200–239 vs <200 | 0.216 | .924 | −0.017 | .982 | 0.470 | .231 | ||||||
| >240 vs <200 | −0.850 | .703 | 0.006 | .994 | 0.379 | .272 | ||||||
| MMSE | ||||||||||||
| Total cholesterol | ||||||||||||
| 200–239 vs <200 | −0.280 | .955 | −1.331 | .460 | −0.271 | .755 | ||||||
| >240 vs <200 | 4.875 | .331 | −0.257 | .887 | −1.291 | .133 | ||||||
Notes: All models control for age, race, education, serum creatinine levels, lipid-lowering drug use, depression, and vascular disease. For all cognitive tests, a negative number means better performance.
SD = standard deviation; TMT-A = Trail Making Test, Part A; HDL = high-density lipoprotein; TMT-B = Trail Making Test, Part B; HVLT-R = Hopkins Verbal Learning Test-Revised; MMSE = Mini-Mental State Examination.