Table 2.

Polymorphisms of genes encoding C-type lectin receptors, RIG-I-like receptors, and proteins of their specific signaling pathways that have known functional consequences and may be relevant to oncogenomics

Gene	Single nucleotide polymorphism
Genes encoding CLRs
MRC1	rs1926736*
	rs2478577*
	rs2437257*
	rs691005*
	rs2477664
	rs692527
	rs2253120
	rs2477637
CD209	rs2287886*
	rs735239*
	rs4804803*
	rs735240*
CLEC7A	rs16910526*
	I223S
Genes encoding RLRs
RIG-I	rs36055726*
	rs11795404*
	rs10813831*
	rs3824456
	rs669260
	rs9650702
	rs626214
	rs592515
	rs6476363
	rs3739674
	rs10813829
	rs4633144
	rs10813821
Genes encoding proteins of CLR and RLR intracellular signaling pathways
MAVS/VISA/IPS-1	rs11905552
	rs17857295
	rs2326369
	rs7269320

Note:

^*Single nucleotide polymorphisms that can be valued as the most promising for further oncogenomic investigation.

Abbreviations: PRRs, pattern recognition receptors; PAMPs, pathogen-associated molecular patterns; DAMPs, damage-associated molecular patterns; TLRs, Toll- like receptors; NLRs, NOD-like receptors; CLRs, C-type lectin receptors; RLRs, RIG- I-like receptors; SNPs, single nucleotide polymorphisms; MRC, mannose receptor C; CD, cluster of differentiation; CLEC, C-type lectin domain, the next number is the family number 7, the next letter is the letter of family member; HIV, human immunodeficiency virus; LY, lymphocyte antigen; DEC-205, dendritic and epithelial cells 205 kDa; DC- SIGN, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; HCV, hepatitis C virus; CMV, cytomegalovirus; DCIR, dendritic cell immunoreceptor; RIG-I, retinoic acid-inducible gene I; EBV, Epstein–Barr virus; CARD, caspase recruitment domain; MAVS, mitochondrial antiviral signaling protein; IFIH, interferon induced with helicase C domain; MDA, melanoma differentiation-associated gene; VISA, virus- induced signaling adapter; IPS-1, induced by phosphate starvation-1.