Table 2.
Platelet aggregation
| LTA 5 μmol/L ADP (%) |
LTA 10 μmol/L ADP (%) |
LTA 20 μmol/L ADP (%) |
VN-P2Y12 result (PRU) | VN-P2Y12 inhibition (%) | |
|---|---|---|---|---|---|
| PON1 QQ192 (AA) (n = 63) | 31.1 ± 12.2 | 37.8 ± 13.7 | 45.2 ± 10.8 | 192.9 ± 70 | 23.8 ± 20 |
| PON1 QR192 (AG) (n = 67)# | 30.8 ± 15.7 | 37.7 ± 16 | 45.3 ± 13.6 | 205.9 ± 88 | 27.4 ± 27 |
| PON1 RR192 (GG ) (n = 21)# | 32 ± 12.8 | 43.6 ± 10.9 | 48.6 ± 11.7 | 239.1 ± 53 | 12.6 ± 17 |
| P-value (univariate) | 0.7 | 0.74 | 0.96 | 0.167 | 0.913 |
| P-value (multivariate) | 0.81 | 0.89 | 0.87 | 0.081 | 0.638 |
|
| |||||
| 2C19*2 Carriers (n = 44)# | 37.9 ± 12 | 45.0 ± 13.1 | 51.3 ± 11 | 234.6 ± 67 | 12.9 ± 14 |
| 2C19*2 Noncarriers (n = 107)# | 29.9 ± 11.2 | 36.2 ± 14.3 | 43.6 ± 12 | 195.0 ± 78 | 27.7 ± 25 |
| P-value (univariate) | 0.037 | 0.034 | 0.034 | 0.027 | 0.013 |
| P-value (multivariate) | 0.04 | 0.036 | 0.034 | 0.014 | 0.012 |
Note:
#
Values represent the mean plus or minus the standard deviation.
Abbreviations: ADP, adenosine diphosphate; LTA, light transmittance aggregometry; PON1, paraoxonase-1; PRU, platelet reactivity units; VN, VerifyNow®.