Table 1.
Pharmacokinetic parameters of buspirone in control and pomegranate treated rabbits.
| Control | R1 | R2 | R3 | R4 | R5 | R6 | Mean ± SD |
|---|---|---|---|---|---|---|---|
| Cmax (ng/ml) | 26.5 | 43.5 | 37.5 | 38.4 | 34.3 | 23.6 | 32.39±7.5 |
| Tmax (hr) | 1.0 | 2.0 | 2.0 | 2.0 | 2.0 | 1.0 | 1.67±0.51 |
| AUC0–24(ng-hr/ml) | 259.8 | 445.9 | 406.9 | 348.2 | 395.4 | 230.7 | 349.26±5.82 |
| AUC0–8(ng-hr/ml) | 280.5 | 470.5 | 448.9 | 358.4 | 444.4 | 239.1 | 373.45±96.99 |
| T1/2 (hr) | 5.9 | 5.1 | 6.5 | 4.1 | 7.0 | 4.4 | 5.48±1.14 |
| Treated | |||||||
| Cmax (ng/ml) | 170.8 | 164.516 | 151.88 | 157.08 | 160.9 | 166.22 | 161.89±6.7 |
| Tmax (hr) | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| AUC0–24(ng-hr/ml) | 1766.7 | 1687.1 | 1644.2 | 1671.8 | 1763.8 | 1712.9 | 1708.77±49.81 |
| AUC0–8(ng-hr/ml) | 1955.7 | 1853.11 | 1806.1 | 1886.2 | 2023.1 | 1929.4 | 1908.26±77.25 |
| T1/2 (hr) | 6.81 | 6.67 | 6.65 | 7.41 | 7.87 | 7.53 | 7.15±0.51 |