Table 3.
The percentage of survived rabbits and colony-forming units (CFU) in different organs of infected-rabbits.
| Treatment | Tissue/Organ | Log CFU Gram tissue (n=3) | Percentage of survival 15 day after the therapy (n=10) |
|---|---|---|---|
| Lung | 4.312±0.5 | ||
| Liver | 4.801±0.4 | ||
| Control without drug administration | Kidney | 4.923±1.1 | None survived |
| (received physiological saline) | Spleen | 4.742±1.3 | |
| Brain | 4.221±1.6 | ||
| Lung | 4.310±0.3 | ||
| Liver | 4.843±0.7 | ||
| Empty nanospheres | Kidney | 4.901±0.8 | None survived |
| (1 mg Kg−1, I.V.) | Spleen | 4.698±0.9 | |
| Brain | 4.250±1.1 | ||
| Lung | 4.017±0.03 | ||
| Free AmB | Liver | 4.216±0.13 | |
| (1 mg Kg−1, I.V.) | Kidney | 4.736±0.19 | 20 |
| Spleen | 4.380±1.1 | ||
| Brain | 3.510±0.20 | ||
| Lung | 1.193±0.04 * | ||
| AmB-loaded nanospheres | Liver | 1.189±0.03 * | |
| (1 mg Kg−1, I.V.) | Kidney | Nil ** | 90 |
| Spleen | Nil ** | ||
| Brain | 1.116±0.03 * |
The values are expressed as mean±S.E.M. from three separate experiments. Analysis of variance of one-way classification between the treatment means was heterogeneous and the t-test values (two-tailed) were significant
*
p < 0.05
**
p < 0.001