Table A5. Full outputs of all analysis models presented in main paper (for stage III/IV vs I/II comparisons).
Complete case analysis
|
Multiple imputation
|
Missing stage=stage III/IV
|
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OR | 95% LCI | 95% UCI | OR | 95% LCI | 95% UCI | FMI | OR | 95% LCI | 95% UCI | |
(a) Breast cancer, stage III/IV vs stage I–II | ||||||||||
15–39 | 1.15 | 0.89 | 1.48 | 1.13 | 0.88 | 1.46 | 0.062 | 1.08 | 0.87 | 1.34 |
40–44 | 1.02 | 0.81 | 1.28 | 1.01 | 0.80 | 1.27 | 0.069 | 0.85 | 0.70 | 1.05 |
45–49 | 0.91 | 0.74 | 1.14 | 0.91 | 0.73 | 1.13 | 0.088 | 0.85 | 0.70 | 1.02 |
50–54 | 0.92 | 0.74 | 1.14 | 0.90 | 0.72 | 1.11 | 0.066 | 0.93 | 0.78 | 1.11 |
55–59 | 0.90 | 0.72 | 1.12 | 0.88 | 0.71 | 1.09 | 0.058 | 0.81 | 0.67 | 0.98 |
60–64 | 0.91 | 0.74 | 1.12 | 0.89 | 0.73 | 1.10 | 0.076 | 0.86 | 0.72 | 1.02 |
65–69 | Ref. | Ref. | Ref. | |||||||
70–74 | 1.21 | 0.98 | 1.49 | 1.22 | 0.99 | 1.50 | 0.064 | 1.08 | 0.90 | 1.29 |
75–79 | 1.46 | 1.20 | 1.78 | 1.50 | 1.23 | 1.82 | 0.062 | 1.30 | 1.09 | 1.54 |
80–84 | 1.68 | 1.37 | 2.07 | 1.75 | 1.43 | 2.15 | 0.115 | 1.77 | 1.49 | 2.10 |
⩾85 | 1.78 | 1.45 | 2.18 | 1.86 | 1.52 | 2.27 | 0.128 | 2.21 | 1.87 | 2.62 |
Most affluent | Ref. | Ref. | Ref. | |||||||
2 | 1.16 | 1.02 | 1.32 | 1.20 | 1.05 | 1.36 | 0.107 | 1.12 | 1.00 | 1.25 |
3 | 1.12 | 0.98 | 1.28 | 1.16 | 1.02 | 1.32 | 0.091 | 1.07 | 0.95 | 1.19 |
4 | 1.29 | 1.12 | 1.49 | 1.32 | 1.15 | 1.52 | 0.116 | 1.21 | 1.07 | 1.36 |
Deprived | 1.23 | 1.00 | 1.52 | 1.27 | 1.03 | 1.57 | 0.149 | 1.07 | 0.89 | 1.29 |
Infiltrating ductal carcinoma | Ref. | Ref. | Ref. | |||||||
Lobular carcinoma | 1.59 | 1.39 | 1.81 | 1.62 | 1.42 | 1.84 | 0.061 | 1.54 | 1.38 | 1.73 |
Mixed ductal lobular | 1.09 | 0.90 | 1.32 | 1.10 | 0.91 | 1.33 | 0.051 | 0.97 | 0.82 | 1.15 |
Other adenocarcinoma | 0.99 | 0.79 | 1.25 | 0.98 | 0.78 | 1.23 | 0.058 | 0.99 | 0.82 | 1.20 |
Other specified carcinoma | 0.58 | 0.26 | 1.26 | 0.58 | 0.27 | 1.27 | 0.118 | 0.90 | 0.52 | 1.54 |
Other unspecified | 3.90 | 3.26 | 4.66 | 4.01 | 3.37 | 4.77 | 0.254 | 4.57 | 3.93 | 5.32 |
Specified not carcinoma | 3.57 | 0.28 | 46.04 | 1.78 | 0.14 | 22.25 | 0.870 | 81.48 | 19.36 | 342.93 |
Screening detection status- no | Ref. | |||||||||
Screening detection status-yes | 0.26 | 0.22 | 0.31 | 0.27 | 0.22 | 0.32 | 0.030 | 0.20 | 0.17 | 0.24 |
(b) Lung cancer, odds ratios of stage III/IV vs stage I/II | ||||||||||
Women | Ref. | Ref. | Ref. | |||||||
Men | 1.14 | 1.03 | 1.25 | 1.13 | 1.03 | 1.25 | 0.170 | 1.15 | 1.05 | 1.27 |
15–49 | 1.33 | 0.93 | 1.90 | 1.23 | 0.86 | 1.75 | 0.197 | 1.31 | ||
50–54 | 1.00 | 0.74 | 1.35 | 0.96 | 0.71 | 1.30 | 0.157 | 0.95 | 0.93 | 1.84 |
55–59 | 1.26 | 0.99 | 1.61 | 1.22 | 0.96 | 1.55 | 0.119 | 1.23 | 0.71 | 1.27 |
60–64 | 0.96 | 0.79 | 1.18 | 0.95 | 0.78 | 1.16 | 0.150 | 0.95 | 0.97 | 1.56 |
65–69 | Ref. | Ref. | 0.78 | 1.15 | ||||||
70–74 | 0.82 | 0.68 | 0.97 | 0.80 | 0.68 | 0.96 | 0.109 | 0.82 | 0.69 | 0.98 |
75–79 | 0.74 | 0.62 | 0.88 | 0.72 | 0.60 | 0.86 | 0.171 | 0.75 | 0.64 | 0.89 |
80–84 | 0.73 | 0.61 | 0.88 | 0.73 | 0.61 | 0.87 | 0.16 | 0.78 | 0.65 | 0.93 |
⩾85 | 0.66 | 0.54 | 0.81 | 0.68 | 0.55 | 0.83 | 0.23 | 0.76 | 0.62 | 0.92 |
Most affluent | Ref. | Ref. | Ref. | |||||||
2 | 0.94 | 0.81 | 1.09 | 0.97 | 0.84 | 1.12 | 0.138 | 0.95 | 0.82 | 1.10 |
3 | 0.97 | 0.83 | 1.12 | 1.01 | 0.87 | 1.17 | 0.184 | 0.97 | 0.84 | 1.12 |
4 | 0.98 | 0.84 | 1.14 | 1.04 | 0.89 | 1.21 | 0.209 | 0.99 | 0.86 | 1.15 |
Deprived | 0.81 | 0.66 | 0.99 | 0.91 | 0.75 | 1.10 | 0.186 | 0.82 | 0.67 | 0.99 |
Adenocarcinoma | Ref. | Ref. | Ref. | |||||||
Squamous cell carcinoma | 0.91 | 0.79 | 1.05 | 0.89 | 0.77 | 1.02 | 0.116 | 0.83 | 0.72 | 0.95 |
Other non-small cell types | 2.07 | 1.77 | 2.42 | 1.97 | 1.70 | 2.29 | 0.099 | 1.87 | 1.61 | 2.18 |
Small cell carcinoma | 4.06 | 3.23 | 5.12 | 3.90 | 3.10 | 4.92 | 0.207 | 3.94 | 3.14 | 4.94 |
Large cell carcinoma | 1.51 | 0.97 | 2.36 | 1.44 | 0.93 | 2.22 | 0.065 | 1.29 | 0.83 | 1.99 |
Carcinoida | 0.02 | 0.00 | 0.18 | 0.02 | 0.00 | 0.15 | 0.764 | 1.53 | 0.87 | 2.70 |
Specified othera | 0.41 | 0.03 | 6.63 | 0.74 | 0.06 | 9.27 | 0.627 | 2.30 | 0.29 | 18.35 |
Unspecified other | 1.94 | 1.67 | 2.24 | 1.85 | 1.59 | 2.15 | 0.289 | 2.07 | 1.80 | 2.37 |
Abbreviations: FMI=fraction of missing information (for each respective variable category, it denotes the proportion of the estimation that used imputed missing information); LCI=lower confidence interval; OR=odds ratio; Ref=reference; UCI=upper confidence interval.
For these two groups, large differences are apparent between the analysis under the missing stage=stage IV analysis and either complete case analysis or multiple imputation. Both these groups were small and had a particularly small proportion of patients with observed stage (<20%), most of whom were in stage I/II. The above indicate that the missing stage=stage IV assumption for patients with missing stage in these two groups is unlikely to be reasonable; we nevertheless present findings for consistency.