Table 1. Studies with over 50 cases that have evaluated BRCA1 mutation prevalence in TN cancers.
| Number of cases | BRCA1 mutations (%) | Unselected/selected | Selection criteria | Reference |
|---|---|---|---|---|
| 144 | 20 (14) | Unselected | Collins et al (2009) | |
| 96 | 9 (9) | Selected | Bilateral and/or family history of breast cancer. | Zhang et al (2011) |
| 93 | 32 (34) | Selected | Seen in Genetic clinics and underwent BRCA testing. | Atchley et al (2008) |
| 77 | 12 (16) | Unselected | Gonzalez-Angulo et al (2011) | |
| 64 | 19 (30) | Selected | Ashkenazi Jewish heritage. Tested for founder mutations. | Comen et al (2011) |
| 63 | 8 (13) | Selected and unselected | TN <41 years | Evans et al (2011) |
| 54 | 5 (9) | Selected | TN <40 years and did not qualify for testing according to ASCO guidelines | Young et al (2009) |
Abbreviation: TN=Triple-negative.