Table 1. Univariate and multivariate analysis for death from prostate cancer.
|
Univariate analysis
|
Multivariate analysis
|
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|---|---|---|---|---|---|---|---|---|
| Variable | N | χ2 (1 df) | Hazard ratio (95% CI) | P-value | N | χ2 (1 df) | Hazard ratioa (95% CI) | P-value |
| CCP score | 349 | 37.6 | 2.02 (1.62, 2.53) | 8.6 × 10−10 | 349 | 17.7 | 1.65 (1.31, 2.09) | 2.6 × 10−5 |
| Gleason score | ||||||||
| <7 | 106 | 36.4 | 0.46 (0.25, 0.86) | 1.6 × 10−9 | 106 | 12.1 | 0.61 (0.32, 1.16) | 5.0 × 10−4 |
| 7 | 152 | 1 (ref) | 152 | 1 (ref) | ||||
| >7 | 91 | 2.70 (1.72, 4.23) | 91 | 1.90 (1.18, 3.07) | ||||
| log (1+PSA) (ng ml−1) | 349 | 16.8 | 1.70 (1.31, 2.20) | 4.2 × 10−5 | 349 | 5.7 | 1.37 (1.05, 1.79) | 0.017 |
| Extent of disease b | ||||||||
| <50% | 69 | 14.1 | 0.50 (0.22, 1.12) | 0.0002 | ||||
| 50–<100% | 106 | 1 (ref) | ||||||
| 100% | 160 | 1.66 (1.01, 2.73) | ||||||
| Age at diagnosis (years) | 349 | 0.05 | 1.00 (0.96, 1.04) | 0.82 | ||||
| Clinical stage | ||||||||
| T1 | 38 | 3.72 | 0.75 (0.32, 1.75) | 0.054 | ||||
| T2 | 106 | 1 (ref) | ||||||
| T3 | 43 | 1.74 (0.90, 3.38) | ||||||
| Hormone use | ||||||||
| No | 200 | 10.2 | 1 (ref) | 0.001 | ||||
| Yes | 149 | 1.97 (1.30, 2.98) | ||||||
Abbreviations: χ2=chi-square; df=degrees of freedom; CI=confidence interval; ref=reference category; PSA=prostate-specific antigen.
Gleason score assessed with 2df for computing the hazard ratios in the multivariate analysis.
Proportion of positive cores.