Table 1. Characteristics of patients with DCIS in the study.

	Breast-conserving surgery+radiotherapy (N=72)	Breast-conserving surgery (N=141)	P-value
Age mean (range) (years)	54.4 (33.4, 81.6)	58.1 (27, 86)	0.04
Tumour size (cm)
Mean (range)	1.2 (0.09, 5.0)	0.8 (0.02, 2.5)	<0.001
Comedo necrosis
Yes	48 (67%)	87 (62%)	0.48
No	20 (28%)	53 (37%)
Missing	4 (5%)	1 (1%)
Nuclear grade
Low	5 (7%)	20 (14%)	0.034
Moderate	27 (38%)	65 (46%)
High	38 (53%)	56 (40%)
Missing	2 (2%)
Multifocality
Yes	33 (46%)	50 (35%)	0.14
No	39 (54%)	91 (65%
Microinvasion
Yes	4 (6%)	4 (3%)	0.32
No	68 (94%)	137 (97%)
Size of negative margin (mm)
⩽3	40 (56%)	78 (61%)	0.61
4–9	10 (14%)	22 (17%)
⩾10	19 (27%)	24 (19%)
Missing	2 (3%)	4 (3%)
Molecular markers
HER2/neu+	19 (26.4%)	39 (27.8%)	0.84
Psoriasin continuous	7.9 (0 ,100)	5.2 (0, 90)	0.27
Psoriasin (⩾10%)	18 (25.0%)	20 (14.2%)	0.051
Calgranulin continuous	5.2 (0, 75)	11.1 (0, 100)	0.06
Calgranulin (⩾10%)	11 (15.3%)	31 (22.0%)	0.24
Ki67 continuos	12.9 (0, 80)	13.4 (0, 80)	0.82
Ki67 (⩾10%)	49 (68.1%)	91 (64.5%)	0.61
p53–continuous	41.9 (0, 100)	15.1 (0, 100)	<0.001
p53+(⩾10%)	44 (61.1%)	39 (27.7%)	<0.001
ER positive	59 (81.9%)	94 (66.7%)	0.02
PR positive	52 (72.2%)	83 (58.9%)	0.06
Cyclin D1	71.5 (0, 100)	78.8 (0, 100)	0.047
p21–continuous	20.1 (0, 100)	20.1 (0, 100)	0.99
p21+(⩾10%)	41 (57.0%)	74 (52.4%)	0.54