Table 2. Histological predictors of local recurrence following breast-conserving surgery alone for DCIS: multivariable analysis (adjusted for age at diagnosis).

Outcome	HR (95% CI)	P-value
Any local recurrence
High nuclear grade	2.21 (1.14, 4.29)	0.02
Multifocality	2.09 (1.09, 4.01)	0.03
Tumour size	1.01 (0.94, 1.07)	0.89
Margin size	0.96 (0.86, 1.06)	0.40
Architectural subtype (solid vs other)	0.92 (0.45, 1.86)	0.82
DCIS recurrence
High nuclear grade	4.09 (1.49, 11.23)	0.01
Multifocality	2.66 (1.03, 6.88)	0.04
Tumour size	1.04 (0.95, 1.13)	0.42
Margin size	1.01 (0.87, 1.16)	0.95
Architectural subtype (solid vs other)	1.35 (0.45, 4.03)	0.59
Invasive recurrence
High nuclear grade	1.27 (0.49, 3.32)	0.62
Multifocality	1.66 (0.66, 4.17)	0.28
Tumour size	0.97 (0.88, 1.07)	0.54
Margin size	0.92 (0.79, 1.07)	0.28
Architectural subtype (solid vs other)	0.66 (0.26, 1.72)	0.40