Table 1. Impact of clinicopathological factors and protein expression/activation on patient survival.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Numbers | P-value | P-value | HR | |
| Age (<60/>60) | 23/35 | 0.287 | ||
| T-stage (Ta/T1/T2/T3/T4) | 27/20/10/1/0 | <0.001 | <0.001 | 3.22 (1.97–5.24) |
| Grade (1/2/3) | 11/25/22 | <0.001 | — | — |
| c-Src nuc (negative/positive) | 37/21 | 0.418 | — | — |
| c-Src cyto (negative/positive) | 31/27 | 0.308 | — | — |
| c-Src mem (negative/positive) | 30/28 | 0.22 | — | — |
| Y527 Src nuc (negative/positive) | 56/2 | 0.008 | — | — |
| Y527 Src cyto (negative/positive) | 37/21 | 0.405 | — | — |
| Y527 Src mem (negative/positive) | 26/32 | 0.01 | — | — |
| Y416 Src nuc (negative/positive) | 30/28 | 0.647 | — | — |
| Y416 Src cyto (negative/positive) | 29/29 | 0.264 | — | — |
| Y416 Src mem (negative/positive) | 33/25 | 0.001 | 0.008 | 0.288 (0.11–0.72) |
| Y861 FAK nuc (negative/positive) | 52/6 | 0.995 | — | — |
| Y861 FAK cyto (negative/positive) | 38/20 | 0.732 | — | — |
| Y861 FAK mem (negative/positive) | 25/33 | 0.008 | — | — |
| Cav nuc (negative/positive) | 57/1 | 0.042 | — | — |
| Cav cyto (negative/positive) | 31/27 | 0.689 | — | — |
| Cav mem (negative/positive) | 44/14 | 0.177 | — | — |
| Rho nuc (negative/positive) | 29/29 | 0.186 | — | — |
| Rho cyto (negative/positive) | 30/28 | 0.712 | — | — |
| Rho mem (negative/positive) | 31/27 | 0.425 | — | — |
Abbreviations: Cav=caveolin; cyto=cytoplasmic; FAK=focal adhesion kinase; HR=hazards ratio; mem=membrane; nuc=nuclear.
Each clinical and pathological parameter was correlated to survival (P-values). Figures in bold denote significant values..