Figure 5.

Inhibition of K-562 cell proliferation by unmodified and boronated RNase A: (●) unmodified RNase A (IC₅₀ >50 μM); (◆) boronated RNase A (IC₅₀ 4.1 ± 0.4 μM); (◇) boronated RNase A in the presence of fructose (50 mM) (IC₅₀ 9 ± 1 μM); (□) boronated RNase A alkylated with 2-bromoacetate (IC₅₀ >50 μM). The proliferation of K-562 cells was measured by the incorporation of [methyl-³H]thymidine. Each data point represents the mean ± standard error of the mean for three separate experiments performed in triplicate.