Table 1.
Baseline Characteristics of Adolescent Girls with Anorexia Nervosa and Normal-Weight Controls
| Controls (n=40) | Anorexia Nervosa (n=110) | P (Controls vs. AN) | |
|---|---|---|---|
| Age (y) | 15.6±0.2 | 16.5±0.2 | 0.001 |
| Bone age (y) | 15.8±0.2 | 16.2±0.1 | Ns |
| Weight (kg) | 57.9±1.4 | 47.2±0.5 | <0.0001 |
| Height (cm) | 164.3±0.9 | 164.3±0.6 | Ns |
| BMI (kg/m2) | 21.4±0.5 | 17.4±0.1 | <0.0001 |
| %IBW (BMI) | 106.3±2.4 | 84.6±0.6 | <0.0001 |
| Tanner stage (breasts) | 4.7±0.1 | 4.6±0.1 | Ns |
| Tanner stage (pubic hair) | 4.6±0.1 | 4.5±0.1 | Ns |
| Amenorrhea duration (y) | - | 0.90±0.08 | - |
| Exercise activity (h) | 16.5±1.7 | 16.8±1.3 | Ns |
| Calcium intake (mg) | 1180±85 | 2040±84 | <0.0001 |
| Vitamin D intake (IU) | 191±28 | 554±28 | <0.0001 |
| DXA Measures | |||
| Fat mass (kg) | 15.9±0.8 | 8.9±0.3 | <0.0001 |
| Lean mass (kg) | 42.0±0.8 | 37.7±0.4 | <0.0001 |
| Percent body fat | 26.2±0.8 | 18.2±0.5 | <0.0001 |
| Lumbar BMD (g/cm2) | 0.972±0.016 | 0.907±0.010 | 0.0009 |
| Lumbar BMD Z-score | 0.136±0.1476 | −0.623±0.098 | <0.0001 |
| Lumbar BMAD (g/cm3) | 0.152±0.0025 | 0.140±0.001 | <0.0001 |
| Hip BMD (g/cm2) | 0.974±0.0189 | 0.887±0.011 | <0.0001 |
| Hip BMD Z-score | 0.277±0.1793 | −0.644±0.098 | <0.0001 |
| Biochemical Parameters | |||
| Vitamin D (ng/ml) | 23.1±1.6 | 31.8±0.9 | <0.0001 |
| PTH (pg/ml) | 11.2±1.8 | 20.3±1.9 | 0.004 |
| Estradiol (pg/ml) | 66.2±13.3 | 39.6±5.4 | 0.03 |
| IGF-1 (ng/ml) | 361.6±16.2 | 239.3±11.3 | <0.0001 |
| Leptin (ng/ml) | 12.4±1.0 | 4.6±0.4 | <0.0001 |
| P1NP (ng/ml) | 200.8±23.8 | 110.6±13.9 | 0.0007 |
| CTX (ng/ml) | 1.01±0.06 | 0.78±0.04 | 0.002 |
Ns: not significant