Table 6.
MIC of different antibiotics after the association of the extract of Garcinia kola seeds at MIC/2, MIC/5 against ten MDR bacteria strains.
| Antibiotics | Extract concentration | Bacterial strains, MIC (μg/mL) of antibiotics in the absence and presence of the extract | |||||||||
| AG100 | AG100Atet | AG102 | CM64 | EA3 | EA27 | KP55 | KP63 | EA289 | PA124 | ||
|
| |||||||||||
| CIP | 0 MIC/2 MIC/5 |
≤0.5 ≤0.5 ≤0.5 |
128 64(2)S 64(2)S |
32 8(4)S 8(4)S |
≤0.5 ≤0.5 ≤0.5 |
256 128(2)S 128(2)S |
≤0.5 ≤0.5 ≤0.5 |
256 128(2)S 256(1)I |
128 32(4)S 128(1)I |
64 32(2)S 64(1)I |
32 <0.5 16(2)S |
| CHL | 0 MIC/2 MIC/5 |
4 4(1)I 4(1)I |
>512 512(>1) 512(>1) |
128 16(8)S 32(4)S |
512 256(2)S 512(1)I |
512 512(1)I 512(1)I |
64 8(8)S 16(4)S |
32 32(1)I 32(1)I |
512 128(4)S 256(2)S |
512 128(4)S 256(2)S |
64 32(2)S 32(2) S |
| STR | 0 MIC/2 MIC/5 |
4 2(2)S 2(2)S |
>512 >512 >512 |
<0.5 <0.5 <0.5 |
512 256(2)S 512(1)I |
>512 >512 >512 |
16 8(2)S 16(1)I |
16 8(2)S 16(1)I |
128 128(1)I 128(1)I |
16 8(2)S 16(1)I |
>512 16(>32)S 128(>4)S |
| AMP | 0 MIC/2 MIC/5 |
32 8(4)S 32(1)I |
>512 >512 >512 |
256 128(2)S 128(2)S |
>512 >512 >512 |
>512 >512 >512 |
64 64(1)I 64(1)I |
>512 >512 >512 |
>512 512 512 |
>512 >512 >512 |
>512 64(>8)S 256(>2)S |
| TET | 0 MIC/2 MIC/5 |
64 32(2)S 32(2)S |
256 128(2)S 128(2)S |
8 2(4)S 2(4)S |
128 64(2)S 64(2)S |
512 256(2)S 256(2)S |
8 2(4)S 4(2)S |
8 2(4)S 4(2)S |
16 4(4)S 16(1)I |
32 8(4)S 8(4)S |
8 4(2)S 8(1)I |
| CLX | 0 MIC/2 MIC/5 |
32 16(2)S 32(1)I |
>512 >512 >512 |
>512 512 512 |
>512 >512 >512 |
>512 >512 >512 |
128 32(4)S 128(1)I |
>512 >512 >512 |
>512 >512 >512 |
>512 >512 >512 |
>512 128(>4)S >512 |
| KAN | 0 MIC/2 MIC/5 |
≤4 ≤4 ≤4 |
512 32(16)S 256(2)S |
16 16(1)I 16(1)I |
≤4 ≤4 ≤4 |
≤4 ≤4 ≤4 |
>512 512 >512 |
32 4(8)S 16(2)S |
512 256(2)S 512(1)I |
32 ≤4(>8)S 32(1) S |
128 16(8)S 64(2)S |
| ERY | 0 MIC/2 MIC/5 |
64 16(4)S 64(1)I |
512 32(16)S 512(1)I |
16 16(1)I 16(1)I |
256 16(16)S 32(8)S |
64 16(4)S 16(4)S |
8 4(2)S 8(1)I |
64 64(1)I 64(1)I |
128 16(8)S 32(4)S |
128 128(1)I 128(1)I |
256 32(8)S 256(1)I |
| NOR | 0 MIC/2 MIC/5 |
32 8(4)S 16(2)S |
512 128(4)S 256(2)S |
128 64(2)S 128(1)I |
16 4(4)S 8(2)S |
16 8(2)S 8(2)S |
32 8(4)S 32(1)I |
128 32(4)S 128(1)I |
64 8(8)S 16(4)S |
64 32(2)S 32(2)S |
256 256(1)I 256(1)I |
| FEP | 0 MIC/2 MIC/5 |
512 512(1)I 512(1)I |
>512 512 (>1) 512(>1) |
>512 >512 >512 |
>512 256(>2)S 256(>2)S |
>512 >512 >512 |
>512 >512 >512 |
>512 >512 >512 |
512 256(2)S 512(1)S |
512 512(1)I 512(1)I |
>512 512(>1) 512(>1) |
(): fold increase in MIC values of the antibiotics after association with plants extract; S: synergy; I: indifference; AMP: ampicillin; FEP: cefepime; CHL: chloramphenicol; KAN: kanamycin; NOR: norfloxacin; STR: streptomycin; TET: tetracycline; CIP: ciprofloxacin; CLX: cloxacillin; ERY: erythromycin.