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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Bone Miner Res. 2011 Sep;26(9):2194–2203. doi: 10.1002/jbmr.428

Table 1.

QCT and ROI threshold values that yield 100% sensitivity for osteoporosis in 252 adults undergoing CTC screening

Phantomless
QCT		 L1
ROI		 L3
ROI		 T12-L5ave
ROI
Threshold for 100% sensitivity for osteoporosis 90 mg/cc 160 HU 130 HU 145 HU
Sensitivity for osteoporosis 100%
(29/29)		 100%
(29/29)		 100%
(29/29)		 100%
(29/29)
Specificity for osteoporosis
(at 100% sensitivity threshold)* 		63.8%
(143/224)		 46.4%
(104/224)		 54.0%
(121/224)		 53.1%
(119/224)
% below threshold with low BMD at DXA** 87.3%
(96/110)		 83.9%
(125/149)		 83.3%
(110/132)		 84.3%
(113/134)
% above threshold with normal BMD*** 49.6%
(69/139)		 57.3%
(59/103)		 50.8%
(61/120)		 50.8%
(61/120)
Mean measurement
(± SD)		 97.8 mg/cc
(± 27.7 mg/cc)		 152.9 HU
(± 38.3 HU)		 130.5 HU
(± 38.6 HU)		 143.7 HU
(± 36.7 HU)
Measurement range 28–178 mg/cc 62–291 HU 41–245 HU 59–254 HU
Mean patient age above/below threshold 56.4 years/
62.3 years		 55.7 years/
61.2 years		 56.1 years/
61.5 years		 56.1 years/
61.5 years
Mean patient BMI above/below threshold 26.7 kg/m2/
25.4 kg/m2 		26.6 kg/m2/
25.8 kg/m2 		26.8 kg/m2/
25.5 kg/m2 		26.9 kg/m2/
25.4 kg/m2
*

Patients with osteopenia per DXA below each threshold is considered a false positive result

**

Low BMD = osteoporosis or osteopenia

***

By definition, the remaining patients with low BMD above this threshold had only osteopenia at DXA – not osteoporosis