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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Nature. 2011 Jun 8;474(7350):220–224. doi: 10.1038/nature10107

Figure 1. Wnt16 is required for specification of HSCs.

Figure 1

Expression of the HSC markers runx1 (a-b) and cmyb (c-d). Fluorescently labelled HSCs in cd41:gfp (e-f) and cmyb:GFP;kdrl:RFP transgenics (g-h). Expression of the lymphocyte marker rag1 (i-j). Embryos are either uninjected (left column) or injected with 5 ng W16MO (right column). Red arrowheads identify the aorta region (a, c) or individual HSCs (e). Green arrowheads identify unaffected runx1+ neurons (a-b). Yellow arrowheads identify unaffected GFP+ multiciliate cells of the pronephros (e-f). Yellow cells are HSCs (g). Blue arrows identify thymic T cells (i). a-h dorsal up, anterior left. i-j ventral views, anterior up.