Figure 1.

In vitro recordings of persistent firing in the rat postsubiculum.(A) In the normal ACSF without the cholinergic receptor agonist carbachol, a brief current injection (2 s, 50 pA) elicited action potentials only during stimulation. (B) Long-lasting persistent firing. In the presence of carbachol (10 μM), the same current injection caused stable sustained firing lasting several minutes. (C) Self-terminating persistent firing. Under the same conditions as in (B), some cells showed persistent firing that lasted for less than 30 s. (D) Persistent firing induced by shorter stimulation. In the postsubiculum, 200 ms of stimulation was often enough to elicit long-lasting persistent firing. Norm, Normal ACSF; Cch, carbachol. Modified from Yoshida and Hasselmo (2009a).