Figure 2.

Intracellular mechanism supports persistent firing.(A) Long-lasting persistent firing observed in synaptic blockers. Ionotropic glutamate (kynurenic acid) and GABA_A (picrotoxin) blockers were used. (B) Persistent firing was not observed in the absence of calcium in ACSF. (C) CAN current blocker flufenamic acid blocked persistent firing. These results suggest that neurons in the postsubiculum have an ability to induce persistent firing with intrinsic mechanisms to the cells. SB, synaptic blockers; Flufen, flufenamic acid. Modified from Yoshida and Hasselmo (2009a).