Table 3.
Heritability and genetic correlation of PFS and SMS caries scores
| Phenotype | n | PFS | SMS | Shared genetics | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| h2 | SE | pa | R2 | h2 | SE | pb | R2 | rhoG | SE | prhoG=0c | prhoG=1d | ||
| Primary dentition | |||||||||||||
| dfs | 953 | 0.34 | 0.10 | 3 × 10−4 | 0.01 | 0.42 | 0.10 | 2 × 10−5 | 0.00 | 0.76 | 0.08 | 0.001 | 9 × 10−4 |
| Proportion dfs | 953 | 0.53 | 0.11 | 2 × 10−6 | 0.04 | 0.42 | 0.10 | 2 × 10−5 | 0.00 | 0.93 | 0.08 | 5 × 10−6 | 0.208 |
| Permanent dentition | |||||||||||||
| DMFS | 1,939 | 0.27 | 0.06 | 7 × 10−6 | 0.35 | 0.27 | 0.07 | 2 × 10−4 | 0.22 | 1.00 | – | 2 × 10−6 | 1.000 |
| Proportion DMFS | 1,939 | 0.37 | 0.06 | 2 × 10−11 | 0.33 | 0.21 | 0.06 | 2 × 10−4 | 0.21 | 0.98 | 0.08 | 5 × 10−9 | 0.424 |
| Total dentition | |||||||||||||
| dfs + DMFS | 2,378 | 0.19 | 0.04 | 2 × 10−6 | 0.28 | 0.17 | 0.04 | 1 × 10−5 | 0.17 | 1.00 | – | 1 × 10−7 | 1.000 |
| Proportion dfs + DMFS | 2,378 | 0.31 | 0.04 | 2×10−13 | 0.35 | 0.23 | 0.04 | 2 × 10−8 | 0.19 | 0.99 | 0.06 | 6 × 10−13 | 0.422 |
h2 = Residual heritability after adjusting for sex and age; SE = standard error, not applicable for models that converged at rhoG = 1.00; R2 = proportion of trait variance attributable to sex and age; rhoG = genetic correlation, i.e. a measure of the extent to which traits covary due to genes.
a p value that PFS caries is heritable.
b p value that SMS caries is heritable.
c p value that shared genetic risk factors affect both PFS and SMS.
d p value that unshared genetic risk factors differentially affect PFS and SMS.