Table 2.

Functional signalling categories and pathways enriched (FDR ≤ 0.2) with genes whose promoter methylation is associated with childhood SEP

	More methylated in high childhood SEP	More methylated in low childhood SEP
Extra-cellular signalling	NTRK2 (BDNF receptor)	Sensory perception of smell and taste, hormone-mediated signalling
Intra-cellular signalling	MAPK signalling
DNA signalling	DNA packaging, targets of several transcription factors, MIR-510 targets	DNA methylation machinery (MBD4,HEMK2), DICER1
Metabolism	Linoleic acid metabolism

Childhood SEP methylation patterns include genes involved in all levels of cell signalling. Subscripts indicate the source of the category or pathway: GO,⁵¹ KEGG⁴⁷ and mSigDB.⁴⁸