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. 2012 Feb 15;2(2):130–140.

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RAD001 treatment inhibits thyroid tumor cell proliferation of Thrb^PV/PVPten^+/- mice. (A). Representative microphotographs of Ki-67 immunohisto-chemistry on thyroid sections of placebo (control; panel a) and RAD001-treated Thrb^PV/PVPten^+/- mice (panel b). (B). Thyroid cell proliferative index, determined by Ki-67 immunohistochemistry in the control and treated groups, shows a significant reduction in the percentage of proliferating cells in the thyroids of RAD001-treated Thrb^PV/PVPten^+/- mice (open bar) as compared with placebo-treated Thrb^PV/PVPten^+/- mice (closed bar) [56].