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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Alzheimers Dement. 2012;8(2):105–113. doi: 10.1016/j.jalz.2011.05.2416

Table 3.

DTI measures and hippocampal volumes predict decline in MCI over 2.5 years

Univariate Multivariate*
b (95% CI) p b* time (95% CI) p b (95% CI) p b* time (95% CI) p
Fornix FA
 mmse 14.45 (3.48, 25.41) 0.010 0.03 (0.01, 0.04) <0.001 7.05 (−3.39, 17.50) 0.186 0.03 (0.01, 0.04) <0.001
 cdrsum −3.36 (−7.84, 1.12) 0.141 −0.01 (−0.02, −0.01) <0.001 −3.44 (−8.49, 1.61) 0.182 −0.01 (−0.02, −0.01) <0.001
 memory Z 10.06 (3.93, 16.19) 0.001 0.01 (0.001, 0.01) 0.020 7.62 (0.91, 14.35) 0.026 0.01 (0.001, 0.01) 0.020
Fornix MD (x10-2)
 mmse −14.07 (−24.54, −3.60) 0.008 −0.02 (−0.04, −0.01) 0.001 −7.06 (−16.85, 2.74) 0.158 −0.02 (−0.03, −0.01) 0.001
 cdrsum 3.64 (−0.43, 7.73) 0.079 0.01 (0.005, 0.02) 0.001 3.72 (−0.81, 8.25) 0.108 0.01 (0.005, 0.02) 0.001
 memory Z −8.74 (−14.81, −2.67) 0.005 −0.004 (−0.01, 0.001) 0.151 −6.09 (−12.56, 0.38) 0.065 −0.004 (−0.009, 0.001) 0.158
Fornix DA (x10-2)
 mmse −37.54 (−62.16, −12.93) 0.003 −0.04 (0.07, −0.01) 0.022 −19.18 (−44.08, 5.73) 0.131 −0.04 (−0.07, −0.005) 0.023
 cdrsum 10.36 (0.43, 20.28) 0.041 0.01 (−0.001, 0.03) 0.060 11.65 (0.27, 23.03) 0.045 0.01 (−0.001, 0.03) 0.057
 memory Z −23.85 (−37.80, −9.90) 0.001 −0.0004 (−0.01−0.01) 0.945 −18.52 (−34.31, −2.74) 0.021 −0.001 (−0.01, 0.01) 0.947
Fornix DR (x10-2)
 mmse −40.54 (−69.44, −11.64) 0.006 −0.02 (−0.06, 0.01) 0.160 −19.53 (−47.07, 8.01) 0.165 −0.02 (−0.06, 0.01) 0.156
 cdrsum 14.04 (3.70, 24.38) 0.008 0.01 (−0.002, 0.03) 0.092 15.40 (3.95, 26.85) 0.008 0.01 (−0.002, 0.03) 0.089
 memory Z −26.52 (−42.07, −10.98) 0.001 0.002 (−0.01, 0.01) 0.721 −20.56 (−37.37, −3.76) 0.016 0.002 (−0.01, 0.01) 0.726
Posterior Cingulate FA
 mmse −8.36 (−31.77, 15.05) 0.484 0.01 (−0.02, 0.03) 0.709 −5.26 (−23.29, 12.78) 0.568 0.004 (−0.02, 0.03) 0.713
 cdrsum 0.68 (−7.92, 9.28) 0.876 −0.002 (−0.01, 0.01) 0.753 0.55 (−7.92, 9.04) 0.898 −0.002 (−0.02, 0.01) 0.744
 memory Z −3.69 (−16.35, 8.96) 0.567 0.004 (−0.004, 0.01) 0.372 −2.86 (−14.07, 8.35) 0.617 0.04 (−0.004, 0.01) 0.375
Posterior Cingulate MD (x10-2)
 mmse −2.39 (−52.93, 48.16) 0.926 −0.02 (−0.06, 0.03) 0.428 −9.48 (−48.21, 29.26) 0.632 −0.02 (−0.06, 0.03) 0.444
 cdrsum 2.61 (−15.54, 20.77) 0.778 0.02 (−0.005, 0.04) 0.129 3.26 (−14.80, 21.31) 0.724 0.02 (−0.005, 0.04) 0.129
 memory Z 10.26 (−17.49, 38.01) 0.469 −0.04 (−0.06, −0.01) 0.006 8.98 (−16.00, 33.96) 0.481 −0.04 (−0.06, −0.01) 0.006
Posterior Cingulate DA (x10-2)
 mmse −170.16 (−335.79, −4.54) 0.044 0.01 (−0.17, 0.19) 0.903 −114.15 (−245.63, 17.33) 0.089 0.01 (−0.17, 0.19) 0.919
 cdrsum 53.06 (−8.67, 14.79) 0.092 −0.01 (−0.09, 0.08) 0.868 49.70 (−12.40, 111.79) 0.117 −0.01 (−0.09, 0.08) 0.866
 memory Z −67.43 (−159.22, 24.36) 0.150 −0.01 (−0.08, 0.05) 0.691 −47.52 (−131.28, 36.24) 0.266 −0.01 (−0.08, 0.05) 0.679
Posterior Cingulate DR (x10-2)
 mmse 7.05 (−173.83, 188.13) 0.938 −0.16 (−0.33, 0.01) 0.071 23.07 (−115.20, 161.33) 0.744 −0.15 (−0.32, 0.01) 0.073
 cdrsum −12.40 (−78.51, 53.70) 0.713 0.03 (−0.05, 0.11) 0.446 −17.52 (−82.33, 47.28) 0.596 0.03 (−0.05, 0.11) 0.442
 memory Z 13.23 (−84.41, 110.88) 0.790 −0.06 (−0.12, −0.01) 0.027 23.31 (−62.56, 109.18) 0.595 −0.06 (−0.12, −0.01) 0.027
Hippocampal/ICV Ratio (x10-2)
 mmse 13.31 (−14.51, 41.14) 0.348 0.11 (0.07, 0.15) <0.001 −4.41 (−30.32, 21.52) 0.739 0.11 (0.07, 0.15) <0.001
 cdrsum −2.44 (−12.98, 8.11) 0.650 −0.05 (−0.06, −0.03) <0.001 −2.89 (−14.98, 9.21) 0.640 −0.05 (−0.06, −0.03) <0.001
 memory Z 11.90 (−3.99, 27.78) 0.142 0.03 (0.01, 0.04) <0.001 4.37 (−12.95, 21.70) 0.621 0.03 (0.01, 0.04) <0.001
*

Controlling for age and education