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. 2012 Mar 15;8(3):e1002553. doi: 10.1371/journal.pgen.1002553

Figure 4. clk-1 mutants are sensitive to alterations in ROS metabolism.

Figure 4

The bars represent the mean defecation cycle length of animals that were scored for one cycle. (A) RNAi mediated knock-down of the mitochondrial localized superoxide dismutases SOD-2 and SOD-3 enhance the slow defecation cycle phenotype of clk-1 mutants (n≥6 for each genotype). (B) NAC (N-acetyl cysteine) supplementation suppresses the slow defecation of clk-1 mutants at 8 and 10 mM concentrations (n≥22 for each genotype). (C) Treatment with 10 mM NAC is without effect on tat-2; clk-1 double mutants (n≥6 for each genotype). The error bars represent S.E.M. *** represents P<0.001, **represents P<0.01, *represents P<0.05.