Table 1.
Ex vivo susceptibility of the 181 isolates of Plasmodium falciparum to pyronaridine (PND), piperaquine (PPQ), chloroquine (CQ), quinine (QN), mefloquine (MQ), monodesethylamodiaquine (MDAQ), lumefantrine (LMF), dihydroartemisinin (DHA) and artesunate (AS)
| IC50 in nM | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drugs | No | geometric mean | 95% Confidence Interval | min | Q25 | median | Q75 | max |
| PND | 176 | 19.9 | 18.0-22.0 | 0.55 | 15.0 | 19.4 | 32.1 | 80.0 |
| PPQ | 179 | 66.8 | 61.8-72.3 | 11.8 | 48.0 | 76.7 | 90.5 | 217.3 |
| CQ | 181 | 79.8 | 66.6-95.6 | 5.0 | 22.9 | 96.0 | 246.0 | 1918.0 |
| QN | 181 | 254.6 | 234.7-276.1 | 54.8 | 182.0 | 265.0 | 358.0 | 1131.0 |
| MQ | 181 | 15.5 | 13.6-17.6 | 3.0 | 8.9 | 15.8 | 29.7 | 166.0 |
| MDAQ | 181 | 22.1 | 19.1-25.6 | 1.5 | 11.8 | 22.6 | 43.3 | 240.0 |
| LMF | 181 | 7.3 | 6.1-8.8 | 0.25 | 5.5 | 8.0 | 17.7 | 114.0 |
| DHA | 181 | 1.3 | 1.2-1.5 | 0.10 | 0.9 | 1.4 | 2.4 | 21.2 |
| AS | 179 | 1.1 | 1.0-1.3 | 0.10 | 0.7 | 1.3 | 2.1 | 20.6 |
Min: IC50 minimum Max: IC50 maximun
Q25: 1st quartile Q75: 3rd quartile