Table 1.
Recovery rate and localization of larvae recovered from different organs of knockout BALB/C mice experimentally infected with human Loa loa.
| Strain | No. of animal dissected | No. of larvae recovered | Subcutaneous tissue | Muscle | Genital organ | Peritoneal cavity | Pleural cavity | Heart and Lungs | Statistics |
|---|---|---|---|---|---|---|---|---|---|
| IL-4 R-α | 14 | 80 | 23(28.75) | 49(61.25) | 5(6.25) | 2(2.50) | 1(1.25) | 0 | - |
| INF-γ KO | 34 | 430 | 296(68.84) | 73(16.98) | 14(3.26) | 25(5.81) | 16(3.72) | 6(1.40) | χ2 = 1058.92 p = 0.0001 |
| IL-5 KO | 48 | 524 | 254(48.47) | 207(39.50) | 9(1.72) | 34(6.49) | 14(2.67) | 6(1.15) | χ2 = 866.30 p = 0.0001 |
| INF-γ/IL-5 DKO | 23 | 283 | 137(48.41) | 112(39.58) | 3(1.06) | 23(8.13) | 7(2.47) | 1(0.35) | χ2 = 472.02 p = 0.0001 |
| IL-4/IL-5 D KO | 27 | 439 | 174(39.64) | 190(43.28) | 5(1.14) | 31(7.06) | 29(6.61) | 10(2.28) | χ2 = 593.43 p = 0.0001 |
| Statistics | χ2 = 95.12 P = 0.0001 |
χ2 = 104.13 P = 0.0001 |
χ2 = 13.64 P = 0.0001 |
χ2 = 3.87 P = 042 |
χ2 = 14.04 P = 0.007 |
- | |||
Each mouse was inoculated with 100 L3 of L. loa. The figures in brackets are the percentages of larvae recovered.