Table 1.
Estrogen antagonist queries derived from CMAP corresponding to raloxfene, fulvestrant and tamoxifen significantly anti-correlate with an estradiol treatment experiment.
| raloxifene | fulvestrant | tamoxifen | ||||
|---|---|---|---|---|---|---|
| SAMPLE | R | N | r | N | R | N |
| GSM155008: 24h_Estradiol_1 | -0.52 | 495 | -0.58 | 496 | -0.45 | 497 |
| GSM155009: 24h_Estradiol_2 | -0.52 | 496 | -0.60 | 498 | -0.43 | 498 |
| GSM155007: 24h_DMSO_2 | -0.21 | 498 | -0.08 | 500 | -0.26 | 499 |
| GSM155006: 24h_DMSO_1 | -0.10 | 493 | 0.13 | 492 | -0.23 | 497 |
| GSM155013: 24h_Tamoxifen_2 | -0.01 | 500 | -0.06 | 497 | 0.04 | 498 |
| GSM155012: 24h_Tamoxifen_1 | 0.39 | 499 | 0.30 | 497 | 0.27 | 499 |
| GSM155005: 24h_Cimicifuga_2 | 0.34 | 497 | 0.39 | 498 | 0.34 | 500 |
| GSM154972: 24h_Cimicifuga_1 | 0.48 | 499 | 0.41 | 499 | 0.39 | 499 |
| Pooled profiles | ||||||
| Estradiol v DMSO | -0.63 | 58 | -0.76 | 90 | -0.46 | 47 |
| Tamoxifen v DMSO | 0.65 | 26 | 0.19 | 24 | 0.67 | 22 |
| Cimicifuga v DMSO | 0.58 | 70 | 0.33 | 75 | 0.56 | 66 |
Positive correlation is seen with tamoxifen treatment and a herbal extract cimicifuga. The regression scores for the pooled treatment and control groups are shown at the bottom of the table.