Table 5.
Summary of major up regulated genes and corresponding pathways involved in Ag-np exposure
| Gene (IMR-90) | Pathways | Genes (U251) | Pathways |
|---|---|---|---|
| Jun oncogene (JUN) |
a) Mitogenic Pathway: b) Wnt Pathway c) PI3 Kinase/AKT Pathway d) Calcium and Protein Kinase C Pathway |
Jun oncogene (JUN) | a) Mitogenic Pathway: b) Wnt Pathway c) PI3 Kinase/AKT Pathway d) Calcium and Protein Kinase C Pathway |
| Bone morphogenetic protein 2 (BMP2) | Hedgehog Pathway | Fibronectin 1 (FN1) | PI3 Kinase/AKT Pathway |
| Interleukin 8 (IL8) | NFκB Pathway | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) (NFκB1) | NFκB Pathway: |
| Colony stimulating factor 2 (granulocyte-macrophage, CSF2) | a) Calcium and Protein Kinase C Pathway b) LDL Pathway |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha(NFκBIA) | NFκB Pathway |
| Transferrin receptor (p90, CD71), (TFRC) | Calcium and Protein Kinase C Pathway | Transferrin receptor (p90, CD71), (TFRC) | Calcium and Protein Kinase C Pathway |
| Growth arrest and DNA-damage-inducible, alpha (GADD45A) | p53 Pathway | ||
| CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) | Insulin Pathway | ||