Table 2.
Altered chromosomal regions showing significant differences between lesions with HPV31 compared to those with HPV16 (FDR < 0.2).
| Number of CIN2/3 cases loss vs. no loss | ||||||
|---|---|---|---|---|---|---|
| Region | Cytoband | HPV16 loss | HPV31 loss | FDR | HPV16 gain | HPV31 gain |
| chr2:222405165-227437895 | 2q36.1-q36.3 | 0 | 3 | 0.123 | 0 | 0 |
| chr2:229728860-238929377 | 2q36.3-q37.3 | 0 | 3 | 0.123 | 0 | 0 |
| chr4:49276564-62563622 | 4p11-q13.1 | 0 | 3 | 0.132 | 1 | 0 |
| chr4:71160319-78914719 | 4q13.3-q21.1 | 0 | 3 | 0.132 | 1 | 0 |
| chr4:79281456-84030000 | 4q21.21-q21.22 | 0 | 3 | 0.132 | 1 | 0 |
| chr4:88363994-132792857 | 4q21.3-q28.3 | 0 | 3 | 0.132 | 1 | 0 |
| chr4:133037098-163174205 | 4q28.3-q32.2 | 0 | 3 | 0.132 | 1 | 0 |
| chr4:163304315-191027815 | 4q32.2-q35.2 | 0 | 3 | 0.132 | 1 | 0 |
| chr6:431607-3540777 | 6p25.3-p25.2 | 0 | 3 | 0.121 | 1 | 0 |
| chr6:7902624-26085970 | 6p24.3-p22.2 | 0 | 3 | 0.121 | 0 | 0 |
| chr6:27956910-31362796 | 6p22.1-p21.33 | 0 | 3 | 0.121 | 0 | 0 |
| chr6:32718990-36975126 | 6p21.32-p21.2 | 0 | 3 | 0.121 | 0 | 0 |
| chr6:42755363-48175246 | 6p21.1-p12.3 | 0 | 3 | 0.121 | 0 | 0 |
| chr6:48648135-106496239 | 6p12.3-q21 | 0 | 3 | 0.121 | 0 | 0 |
| chr6:107106382-169915340 | 6q21-q27 | 0 | 3 | 0.121 | 0 | 0 |
| chr8:142600766-145818157 | 8q24.3 | 0 | 3 | 0.127 | 5 | 3 |
| chr17:3564934-7259932 | 17p13.2-p13.1 | 0 | 3 | 0.122 | 0 | 0 |
| chr17:7328200-10781444 | 17p13.1-p12 | 0 | 3 | 0.122 | 0 | 0 |
| chr17:12531028-22078641 | 17p12-p11.2 | 0 | 3 | 0.122 | 0 | 0 |
| Number of CIN2/3 cases gain vs. no gain |
||||||
| Region | Cytoband | HPV16gain | HPV31gain | FDR | HPV16loss | HPV31loss |
| chr1:107415557-114310216 | 1p13.3-p13.2 | 3 | 7 | 0.163 | 0 | 0 |
| chr1:114666834-146812099 | 1p13.2-q21.2 | 3 | 7 | 0.163 | 0 | 0 |
| chr1:148081768-151210846 | 1q21.2-q21.3 | 3 | 7 | 0.163 | 0 | 0 |
| chr1:151380037-167624107 | 1q21.3-q24.3 | 3 | 7 | 0.163 | 0 | 0 |
| chr1:168079451-172935386 | 1q24.3-q25.2 | 3 | 7 | 0.163 | 0 | 0 |
| chr1:172950731-177727312 | 1q25.2-q25.3 | 2 | 7 | 0.063 | 0 | 0 |
| chr1:177742624-194855793 | 1q25.3-q31.3 | 2 | 8 | 0.029 | 0 | 0 |
| chr1:195212008-208655399 | 1q31.3-q32.3 | 2 | 8 | 0.029 | 0 | 0 |
| chr1:212426726-217520338 | 1q41 | 2 | 8 | 0.029 | 0 | 0 |
| chr1:218155880-223642833 | 1q41-q42.13 | 2 | 8 | 0.029 | 0 | 0 |
| chr1:223683098-230121747 | 1q42.13-q42.2 | 2 | 7 | 0.063 | 0 | 0 |
| chr1:231048153-234780716 | 1q42.3-q43 | 2 | 7 | 0.063 | 0 | 0 |
| chr1:236021319-242608344 | 1q43-q44 | 2 | 8 | 0.029 | 0 | 0 |
| chr1:242848259-246751472 | 1q44 | 2 | 8 | 0.029 | 0 | 0 |
All lesions included in the analysis had > 1.5% aberrations