Table 3.

AL dosing and pharmacokinetic parameters in patients weighing 5 to < 10 kg or 10 to < 15 kg

	Body weight
	5 to < 10 kg	10 to < 15 kg
Artemether & dihydroartemisinin (DHA)
Dispersible tablet	N = 171	N = 352
Total dose artemether (mg/kg)	14.8 ± 2.57	10.0 ± 1.30
Cmax artemether (ng/mL)	372 ± 251	110 ± 97.7
Cmax DHA (ng/mL)	107 ± 76.6	38.2 ± 42.4
Crushed tablet	N = 183	N = 37
Total dose artemether (mg/kg)	14.7 ± 1.94	10.0 ± 1.28
Cmax artemether (ng/mL)	295 ± 214	137 ± 111
Cmax DHA (ng/mL)	89.9 ± 83.5	36.6 ± 28.7
Lumefantrine
Dispersible tablet	N = 24	N = 78
Total dose lumefantrine (mg/kg)	90.4 ± 9.46	60.4 ± 7.37
Cmax (μg/mL)	6.55	5.55
AUC0-last (μg·h/mL)	550	393
Crushed tablet	N = 26	N = 75
Total dose lumefantrine (mg/kg)	88.6 ± 13.1	59.5 ± 6.87
Cmax (μg/mL)	5.50	6.29
AUC0-last (μg·h/mL)	578	558

Data are mean ± SD;¹ N = 18 for DHA;² N = 34 for DHA;³ N = 19 for DHA