. Author manuscript; available in PMC: 2013 Mar 14.

Published in final edited form as: J Am Chem Soc. 2012 Mar 2;134(10):4842–4849. doi: 10.1021/ja211115q

Table 2.

Accessible volume within first and second solvation shell vs. bulk

System	Protein [vol%]	1^st shell (r≤4 Å) [%]	2^nd shell (4 Å < r ≤ 7 Å) [%]	Bulk (r >7 Å) [%]
PG1	10	22.4	14.4	63.3
PG2	14	31.7	20.4	47.9
PG3	20	44.0	24.6	31.5
PG4	30	65.6	26.7	7.7
PGVH1	12	28.1	16.3	55.6
PGVH2	17	37.7	19.1	43.3
PGVH3	25	53.4	22.2	24.5
PGVH4	37	76.2	19.6	4.2
PGVH5	43	86.4	13.0	0.6