Table 3.
Mutually adjusted odds ratios (OR) and 95% confidence intervals (CIs) for the most parsimonious model of the association between host characteristics, MC1R, and BCC in the Yale Study of Skin Health
| Characteristic | Cases/Controls | Mutually adjusted OR1 (95% CI) |
|---|---|---|
| Hair color | ||
| Black/Dark brown | 99/157 | 1.00 |
| Light brown | 135/151 | 1.31 (0.78–1.64) |
| Blonde/Fair | 100/63 | 1.63 (1.04–2.53) |
| Red | 39/11 | 2.74 (1.23–6.09) |
| Skin color | ||
| Olive | 15/74 | 1.00 |
| Fair | 211/232 | 2.75 (1.46–5.18) |
| Very fair | 147/76 | 4.48 (2.21–9.09) |
| MC1R non-synonymous variants | ||
| 0 variants | 65/130 | 1.00 |
| 1 variant | 172/175 | 1.41 (0.95–2.11) |
| ≥ 2 variants | 136/77 | 1.91 (1.20–3.03) |
| Moles ≥ 5 mm on back | ||
| None | 172/204 | 1.00 |
| 0–4 | 136/145 | 1.03 (0.73–1.44) |
| 5–9 | 42/22 | 1.93 (1.05–3.52) |
| 10 or more | 23/11 | 2.19 (0.98–4.90) |
| Skin reaction with first summer sun exposure | ||
| Turn brown, no sunburn | 6/31 | 1.00 |
| Mild sunburn followed by tan | 141/196 | 1.91 (0.73–5.03) |
| Painful sunburn peeling | 196/142 | 2.43 (0.90–6.58) |
| Severe sunburn blistering | 30/13 | 3.68 (1.11–12.23) |
1
Adjusted for age at diagnosis (continuous), body site (head, extremity, trunk), gender and all other characteristics in table.