Table 4.
MC1R non-synonymous variants and BCC risk stratified by host characteristics in the Yale Study of Skin Health
| Characteristic | MC1R Variants | Cases/Controls | OR1 (95% CI) | p for interaction2 |
|---|---|---|---|---|
| Eye color | 0.557 | |||
| Brown | 0 | 17/56 | 1.00 | |
| 1 | 38/71 | 1.64 (0.82–3.29) | ||
| ≥ 2 | 31/23 | 4.37 (1.99–9.56) | ||
| Hazel/Green | 0 | 17/34 | 1.00 | |
| 1 | 52/48 | 2.06 (1.01–4.20) | ||
| ≥ 2 | 42/26 | 2.99 (1.38–6.47) | ||
| Blue/Grey | 0 | 31/41 | 1.00 | |
| 1 | 83/56 | 1.95 (1.08–3.53) | ||
| ≥ 2 | 65/28 | 3.25 (1.67–6.35) | ||
| Hair color | 0.670 | |||
| Black/Dark brown | 0 | 23/62 | 1.00 | |
| 1 | 55/72 | 1.94 (1.05–3.58) | ||
| ≥ 2 | 22/23 | 2.62 (1.20–5.73) | ||
| Light brown | 0 | 24/53 | 1.00 | |
| 1 | 66/69 | 2.00 (1.09–3.67) | ||
| ≥ 2 | 46/30 | 3.12 (1.57–6.19) | ||
| Blonde/Fair/Red | 0 | 18/16 | 1.00 | |
| 1 | 51/34 | 1.23 (0.54–2.80) | ||
| ≥ 2 | 70/24 | 2.44 (1.05–5.65) | ||
| Skin color | 0.364 | |||
| Olive/Fair | 0 | 47/120 | 1.00 | |
| 1 | 111/132 | 2.04 (1.32–3.14) | ||
| ≥ 2 | 69/55 | 3.38 (2.04–5.59) | ||
| Very fair | 0 | 18/11 | 1.00 | |
| 1 | 62/43 | 0.94 (0.39–2.25) | ||
| ≥ 2 | 69/22 | 1.81 (0.72–4.52) | ||
| Skin reaction to first summer sun exposure | 0.851 | |||
| Turn brown, no burn/Mild burn then tan | 0 | 38/96 | 1.00 | |
| 1 | 69/98 | 1.64 (1.00–2.71) | ||
| ≥ 2 | 41/33 | 3.04 (1.64–5.61) | ||
| Painful burn peeling/Severe burn blistering | 0 | 27/34 | 1.00 | |
| 1 | 104/77 | 1.63 (0.90–2.96) | ||
| ≥ 2 | 97/44 | 2.64 (1.41–4.96) | ||
| Skin reaction to prolonged sun exposure | 0.299 | |||
| Very brown/Moderately tanned | 0 | 46/115 | 1.00 | |
| 1 | 102/129 | 1.92 (1.24–2.99) | ||
| ≥ 2 | 59/45 | 3.49 (2.04–5.95) | ||
| Mildly tanned peeling/Freckled, no tan | 0 | 19/16 | 1.00 | |
| 1 | 71/46 | 1.12 (0.51–2.45) | ||
| ≥ 2 | 79/32 | 1.81 (0.81–4.03) | ||
| Moles ≥ 5 mm on back | 0.496 | |||
| None | 0 | 28/74 | 1.00 | |
| 1 | 85/91 | 2.54 (1.48–4.35) | ||
| ≥ 2 | 59/39 | 4.05 (2.20–7.47) | ||
| 0–4 | 0 | 27/52 | 1.00 | |
| 1 | 55/61 | 1.68 (0.92–3.07) | ||
| ≥ 2 | 55/33 | 3.31 (1.72–6.36) | ||
| ≥ 5 | 0 | 10/5 | 1.00 | |
| 1 | 33/23 | 0.51 (0.14–1.89) | ||
| ≥ 2 | 22/5 | 2.26 (0.49–10.46) | ||
| Freckles on face | 0.723 | |||
| None | 0 | 28/68 | 1.00 | |
| 1 | 38/60 | 1.55 (0.83–2.92) | ||
| ≥ 2 | 12/8 | 4.33 (1.54–12.15) | ||
| Very few | 0 | 18/38 | 1.00 | |
| 1 | 38/50 | 1.73 (0.83–3.59) | ||
| ≥ 2 | 26/21 | 2.44 (1.06–5.61) | ||
| Few/Some/Many | 0 | 19/25 | 1.00 | |
| 1 | 97/65 | 1.88 (0.95–3.75) | ||
| ≥ 2 | 100/48 | 2.55 (1.26–5.15) |
1
Adjusted for age at diagnosis (continuous), body site (head, extremity, trunk), and gender.
2
Based on inclusion of cross-product term in multivariate model.