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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2011 Sep 29;64(6):571–588. doi: 10.1016/j.addr.2011.09.010

Figure 12.

Figure 12

Gastrointestinal stability and transpeithelial transport of PAMAM-SN38 complex. A. Schematic representation of G4S5 complex. B. Stability of polymer-SN-38 complexes G4S5 (open squares, solid line) and G4S11 (filled squares, solid line) at pH 7.4, and G4S5 (open circles, dotted line) and G4S11 (filled circles, dotted line) at pH 5. G4S5, G4S11: 5 and 11 moles of SN38 complexed to PAMAM G4.0 respectively. C. Permeability of G4S5, G4S11 and SN-38, across Caco-2 cell monolayers after 120 min With permission from Ref [21].