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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2011 Sep 29;64(6):571–588. doi: 10.1016/j.addr.2011.09.010

Figure 14.

Figure 14

Nuclear fragmentation in HCT-116 cells treated with drug/conjugates. Untreated cells (column 1); 5 nM SN38 (column 2); 40 nM G3.5-gly-SN38 (column 3); 120 nM G3.5-βala-SN38 (column 4). Scale bar is 10 μm. Arrows indicate nuclear fragments. From bottom: 1st row, differential interference contrast image; 2nd row, fluorescence image; 3rd row, overlay of differential interference contrast and fluorescence images. With permission from Ref [53].