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PK parameters of 4b in SD rats
| Route | Dose (mg/kg) |
t
1/2α
(h) |
t
1/2α
(h) |
Vd
ss
(L/kg) |
CL
p
(L/h/kg) |
C
max
(ng/mL) |
T
max
(h) |
AUC
0-9 h
(ng h/mL) |
BA (%) |
|---|---|---|---|---|---|---|---|---|---|
| Iv | 1 | 0.062 | 0.27 | 8.28 | 26.2 | ND | ND | 39 | |
| po | 3 | ND | 1.37 | ND | ND | 37 | 0.25 | 33 | 27.7 |
| 10 | ND | 1.50 | ND | ND | 229 | 0.25 | 156 | 39.9 |
