Figure 2.

Volumetric differences between groups. Colors code the ratio of Williams Syndrome / controls in areas with significant differences between groups. Using voxel-based analysis (A) we detected atrophy in a cluster of voxels in the basal ganglia. The atlas-based analysis of the gray matter (B) and the white matter (C) showed that the basal ganglia, deep white matter regions such as the internal and external capsules, and the commissural tracts such as the anterior commissure, the left tapetum, the right fornix, and the corpus callosum, were reduced in subjects with Williams Syndrome compared to controls. After normalization to a common brain volume, the atlas-based analysis (D) showed atrophy of the caudate and the left globus palladium in Williams Syndrome, and relative preservation of the gray matter of the cerebellum, the right amygdala, the left fusiform, parahippocampus, and the medial temporal gyri.