Figure 3.

AChE variants exert hematopoietic effects through common and distinct protein partners.(A) The common core domain of AChE interacts with laminin. (B) To validate partner interactions, the C-termini of AChE-S and AChE-R were constructed together with GFP. (C) The C-terminus of AChE-S interacts with the anti-apoptogenic nuclear CtBp, whereas intracellular AChE-R interacts with the proliferation activating scaffold PKCβ carrier RACK1 and with Enolase. (D) Fluorescent cell images: GFP constructs direct the AChE-S and AChE-R C-termini to nucleus and cytoplasm, respectively [Perry et al. (2007)].