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Phenotypic responses of yeast pathogens to itraconazole (ITZ) and tert-butyl hydroperoxide (t-BuOOH). Results showed that Candida krusei 6258 and Cryptococcus neoformans CN24, two ITZ-sensitive strains, were also sensitive to t-BuOOH, indicating the correlation between ITZ toxicity and oxidative stress. Results shown here are representative data from the treatment with 1.0 μg mL−1 of ITZ and 1.5 mM of t-BuOOH, respectively.
