Table 2. Cox uni- and multivariable analysis of relative risks of death from colorectal cancer and overall death according to SATB2 expression in all patients, colon and rectal cancer, respectively.
|
Colorectal cancer-specific survival
|
Overall survival
|
|||||
|---|---|---|---|---|---|---|
| HR (95%CI) | P-value | n (events) | HR (95%CI) | P-value | n (events) | |
| All | Univariable | Univariable | ||||
| SATB2 low | 1.00 | 0.020 | 411 (153) | 1.00 | 0.021 | 411 (186) |
| SATB2 high | 0.61 (0.41–0.92) | 116 (27) | 0.65 (0.45–0.94) | 116 (34) | ||
| Multivariable | Multivariable | |||||
| SATB2 low | 1.00 | 0.168 | 372 (134) | 1.00 | 0.184 | 372 (161) |
| SATB2 high | 0.72 (0.45–1.15) | 100 (21) | 0.75 (0.49–1.15) | 100 (26) | ||
| Colon | Univariable | Univariable | ||||
| SATB2 low | 1.00 | 0.005 | 257 (91) | 1.00 | <0.001 | 257 (116) |
| SATB2 high | 0.39 (0.20–0.75) | 64 (10) | 0.31 (0.16–0.60) | 64 (10) | ||
| Multivariable | Multivariable | |||||
| SATB2 low | 1.00 | 0.039 | 236 (80) | 1.00 | 0.003 | 236 (101) |
| SATB2 high | 0.49 (0.25–0.96) | 59 (10) | 0.37 (0.19–0.71) | 59 (10) | ||
| Rectum | Univariable | Univariable | ||||
| SATB2 low | 1.00 | 0.727 | 145 (59) | 1.00 | 0.598 | 145 (67) |
| SATB2 high | 0.90 (0.51–1.59) | 48 (15) | 1.14 (0.70–1.87) | 48 (21) | ||
| Multivariable | Multivariable | |||||
| SATB2 low | 1.00 | 0.864 | 128 (52) | 1.00 | 0.398 | 128 (58) |
| SATB2 high | 1.07 (0.51–2.24) | 37 (9) | 1.32 (0.70–2.48) | 37 (13) | ||
Abbreviations: CI=confidence interval; HR=hazard ratio; SATB2=special AT-rich sequence-binding protein 2; SATB2 low=nuclear score ⩽9; SATB2 high=nuclear score >9.
Multivariate analysis included adjustment for age (>/⩽75 years), gender, T stage (I-II, III, IV), N stage (0,1,2), M stage (0, 1), differentiation grade (high-intermediate vs low) and vascular invasion (absent, present, missing).