Table 2. Summary of pharmacokinetic endpoints for rIL-21 following single (day 8) and multiple (day 43) doses (once weekly) of intravenous rIL-21 in combination with once weekly dosing of cetuximab.

	Day 8 rIL-21 dose (μg kg−1)				Day 43 rIL-21 dose (μg kg−1)
Parameter	3	10	30	100	3	10	30	100
AUC0−24 h (μg h l−1)	—	—	85	617	—	—	115	487
AUC0−168h (μg h l−1)	—	—	85	623	—	—	115	489
AUC0−INF (μg h l−1)	—	—	85	623			115	489
Concentration (C5 min) post i.v. (μg l−1)	—	18	75	435	4.8	3.2	74	286
t½ (h)	—	—	2.1	3.6	—	—	2.1	2.7
CL (ml h−1 kg−1)	—	—	350	160	—	—	260	204
Vz (ml kg−1)	—	—	1080	829	—	—	699	607
MRT (h)	—	—	2.3	3.5	—	—	2.7	3.1

Abbreviations: CL=clearance; MRT=mean residence time; Vz=terminal Vd.