Table 3. Summary of pharmacokinetic endpoints for cetuximab following single (day 8) and multiple (day 43) doses (once weekly) of cetuximab in combination with once weekly dosing of rIL-21.

	Day 8 cetuximab dose rIL-21 (μg kg−1)				Day 43 cetuximab dose rIL-21 (μg kg−1)
Parameter	3	10	30	100	3	10	30	100
AUC0−168 h (μg h l−1)	14 798	11 732	11 268	15 776	10 859	16 576	11 971	12 660
AUC0−INF (μg h l−1)	18 608	14 489	12 850	21 175	13 599	25 699	14 522	15 817
Concentration (C5 min) i.v. (μg l−1)	183	139	160	179	149	173	164	81
t½ (h)	74	59	54	88	72	112	67	73
CL (ml h−1 kg−1)	17	21	22	16	23	15	21	19.7
Vz (ml kg−1)	1432	1675	1443	1679	2126	2202	1614	1680
MRT (h)	89	88.0	67	108	94	151	80	89

Abbreviations: CL=clearance; MRT=mean residence time; Vz=terminal Vd.