Table 5. Univariate and multivariate analysis of local relapse-free, overall disease-specific survival and of metastasis-free survival.

	Local relapse-free survival		Metastasis free-survival		Overall survival
	Risk-ratio	P-value	Risk-ratio	P-value	Risk-ratio	P-value
Univariate (Kaplan–Meier) analysis
Parameter
T-stage	2.85	0.02	1.12	0.89	2.12	0.06
N-stage	2.38	0.02	3.20	0.05	1.66	0.16
Grade	1.10	0.81	1.56	0.47	1.12	0.75
CD44	2.17	0.02	0.57	0.36	1.51	0.24
CD24	1.33	0.52	0.76	0.87	1.18	0.70
Oct4	2.85	0.005	3.20	0.05	1.88	0.08
Integrin-β1	4.54	0.0002	8.30	0.001	2.56	0.01
ALDH1	0.43	0.02	0.43	0.17	0.55	0.09
MIB-1	1.29	0.50	1.50	0.50	0.90	0.77
Multivariate (Cox regression) analysis
Parameter
T-stage	5.19	0.009
N-stage	2.03	0.08	2.68	0.14
Grade
CD44	1.91	0.22
CD24
Oct4	1.05	0.89	2.38	0.17
Integrin-β1	3.08	0.007	5.72	0.01
ALDH1	0.49	0.01
MIB-1

Abbreviation: ALDH1=aldehyde dehydrogenase isoform 1A1.

Results refer to comparison of high vs low groups. Multivariate analysis included only parameters significant at univariate.