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. 2012 Mar 1;26(5):445–460. doi: 10.1101/gad.182477.111

Figure 5.

Figure 5.

Rbfox1+/loxP/Rbfox2loxP/loxP/Nestin-Cre+/– and L7-DKO mice show highly irregular Purkinje cell electrophysiology. (A) Representative contiguous segments of an extracellular recording from a single Purkinje cell (PC) in the various Rbfox/Nestin knockouts. (B) Pooled data for Purkinje cell mean firing frequency and coefficient of variation of interspike intervals (ISI CV) in the various Rbfox/Nestin knockouts. n = 99, 89, 100, and 139 cells for wild type (WT), Rbfox2−/−, Rbfox1−/−/Rbfox2+/–, and Rbfo1+/–/Rbfox2−/−, respectively. (C) Representative contiguous segments of an extracellular recording from a single Purkinje cell in wild-type and L7-DKO mice at age P20 or P70. (D) Pooled data for Purkinje cell mean firing frequency and ISI CV in wild-type and L7-DKO mice. n = 43, 63, 39, and 71 cells for wild-type P20, L7-DKO P20, wild-type P70, and L7-DKO P70, respectively. Error bars, SEM. Statistical significance was calculated by ANOVA testing, followed by post-hoc Tukey paired comparisons with Bonferroni correction for multiple comparisons. (*) P < 0.005; (**) P < 2 × 10−6.