Histone H3K9K14 is hypoacetylated at the promoter regions of genes in young
subjects with schizophrenia and associated with decreased gene expression
levels. (a) ChIP-qPCR assays were performed on young and old subjects
with schizophrenia and age-matched controls (group 2; n=32
subjects in total), measuring ac-H3K9K14 levels at the promoter regions of
the indicated genes (UniGene IDs). Asterisks denote significant differences
in ac-H3K9K14 levels, as determined by Student's t-test:
*, P<0.05, +,
P<0.08. (b) Significant differences in microarray
expression values were determined by ANOVA as described in Materials and
methods; *, P<0.05, **,
P<0.01.