Table 2. Correlation analysis (Pearsons's (r) values) of ChIP-qPCR and gene expression data against age.
|
ChIP-qPCR data
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Gene Expression data:
|
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Normal
|
Schizophrenia
|
Bipolar disorder
|
Normal
|
Schizophrenia
|
Bipolar disorder
|
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| Gene ID | Age, r-value | P-value | Age, r-value | P-value | Age, r-value | P-value | Age, r-value | P-value | Age, r-value | P-value | Age, r-value | P-value |
| RGS4 | −0.658 | 0.020 | −0.079 | 0.788 | −0.241 | 0.406 | −0.503 | 0.056 | −0.307 | 0.285 | −0.879 | <0.0001 |
| PPM1E | −0.731 | 0.007 | 0.306 | 0.288 | −0.681 | 0.007 | −0.579 | 0.023 | −0.350 | 0.221 | −0.809 | 0.001 |
| GAD1-1 | −0.557 | 0.048 | −0.623 | 0.017 | −0.789 | 0.001 | −0.527 | 0.043 | −0.460 | 0.098 | −0.737 | 0.003 |
| GAD1-2 | −0.581 | 0.023 | −0.167 | 0.550 | ND | ND | −0.504 | 0.005 | 0.128 | 0.500 | ND | ND |
| HTR2C-1 | −0.602 | 0.023 | −0.008 | 0.978 | −0.448 | 0.108 | −0.078 | 0.781 | −0.252 | 0.385 | −0.812 | 0.000 |
| HTR2C-2 | −0.429 | 0.111 | −0.245 | 0.361 | ND | ND | −0.499 | 0.006 | 0.244 | 0.194 | ND | ND |
| TOMM70A-1 | −0.756 | 0.002 | −0.132 | 0.652 | −0.604 | 0.022 | −0.491 | 0.063 | −0.384 | 0.175 | −0.829 | 0.000 |
| TOMM70A-2 | −0.261 | 0.341 | 0.266 | 0.320 | ND | ND | −0.529 | 0.003 | 0.271 | 0.148 | ND | ND |
| MBP | −0.682 | 0.005 | 0.416 | 0.109 | ND | ND | −0.505 | 0.005 | 0.590 | 0.001 | ND | ND |
| UGT8 | −0.376 | 0.166 | 0.138 | 0.610 | ND | ND | 0.153 | 0.428 | 0.527 | 0.003 | ND | ND |
| H1FNT | −0.480 | 0.082 | −0.300 | 0.260 | ND | ND | −0.053 | 0.786 | 0.252 | 0.179 | ND | ND |
ND, not determined.
Bold font indicates a statistically significant correlation.
The values for GAD1-2, HTR2C-2, TOMM70A-2, MBP, UGT8 and H1FNT are from subjects in group 2, with the gene expression data reflecting the microarray correlations shown in Supplementary Figure 1.