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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Bone Miner Res. 2011 Sep;26(9):2151–2160. doi: 10.1002/jbmr.425

Figure 2.

Figure 2

Effect of botulinum toxin A (BtxA) on trabecular bone in wild type (WT) and Gja1 conditional knockout (cKO) mice. A. Trabecular bone volume (BV/TV) in injected (BtxA) and control limbs of mice followed for 19 weeks. There was a significant decrease of BV/TV in the tibiae in the BtxA injected limbs compared with control tibiae. a: p < 0.05 vs cKO BtxA Control; b: p < 0.05 vs WT BtxA Control. B. Difference in BV/TV between injected (BtxA or saline) and non-injected control limbs, expressed as a percentage of baseline. Following the injection, the difference (imbalance) between injected and non-injected limbs sharply decreased selectively in the BtxA but not in the saline groups of each genotype. There is a progressive though incomplete recovery thereafter. There was a significant effect of treatment and time (p<0.05) but no effect of genotype by 2-way ANOVA. a: p < 0.05 vs cKO Saline; b: p < 0.05 vs WT Saline. C. Micro-CT generated 3-D reconstruction of metaphyses of WT BtxA and (D) tibiae of cKO BtxA injected limbs at different time-points.