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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Bone Miner Res. 2011 Sep;26(9):2151–2160. doi: 10.1002/jbmr.425

Figure 3.

Figure 3

Effect of botulinum toxin A (BtxA) on cortical bone in wild type (WT) and Gja1 conditional knockout (cKO). A. Difference in Marrow Area (Ma.Ar.) between injected (BtxA or saline) and non-injected control limbs, expressed as a percentage of baseline. There was significant expansion of the marrow cavity for WT mice beginning 3 weeks post BtxA injection and persisting through the 19 weeks of the study. There was a significant effect of genotype and treatment by 2-way ANOVA (p < 0.05). B. Difference in Cortical Area (Ct.Ar) between injected (BtxA or saline) and non-injected control limbs, expressed as a percentage of baseline. There was a significant reduction in relative cortical area over time for the WT BtxA mice. There was a significant genotype effect in the BtxA group (p<0.05) but not in the Saline mice by 2-way ANOVA (p>0.05). No significant changes in Ct.Ar were observed for the cKO BtxA mice over the 19 weeks of the study. C. Micro-CT generated 3-D reconstruction of diaphyses of WT and cKO taken at baseline, 3 weeks and 19 weeks for each genotype. a: p < 0.05 vs cKO Saline, b: p < 0.05 vs WT Saline, c: p < 0.05 vs cKO BtxA, d: p < 0.05 vs WT Baseline.