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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Bone Miner Res. 2011 Sep;26(9):2151–2160. doi: 10.1002/jbmr.425

Figure 4.

Figure 4

The effect of botulinum toxin A (BtxA) on in wild type (WT) and Gja1 conditional knockout (cKO) mice on parameters of bone resorption as determined via TRAP staining for osteoclasts at the mid diaphysis (n=12 per genotype group), and measures of bone formation as determined via calcein labeling. Results are expressed as the absolute difference from the Control limb. A. osteoclast surface/bone surface (OcS/BS) for mice sacrificed 3 weeks after BtxA injection. a: p < 0.05 vs WT Saline. B. Number of osteoclasts per BS (N. Oc./BS) for mice sacrificed 3 weeks after BtxA injection. a: p < 0.05 vs WT Saline. C. Mineralizing surface/bone surface (MS/BS) at the endocortical surface of the mid-diaphysis in mice sacrificed 3 weeks post BtxA injection. D. Mineralizing surface/bone surface (MS/BS) at the periosteal surface of the mid diaphysis. There were no significant differences in terms of mineralizing surface between groups.