Table 2.

Changes in Trabecular Thickness (percent of baseline) in BtxA or Saline Injected Limbs Relative to Non-Injected Control Limbs

Weeks since Injection	3	7	11	15	19
WT Saline	2.07±2.41	4.63±1.98	2.63±4.74	3.81±3.91	8.21±10.81
WT BtxA*	−22.66±6.92b	−6.67±6.17	−0.16±2.36	−0.52±4.04	−0.09±5.27
cKO Saline	0.13±3.14	−1.66±3.29	−0.47±2.37	−3.84±2.05	−3.49±1.76
cKO BtxA*	−24.63±7.98a	−9.67±3.12	−12.87±7.76	−11.72±3.91c	−9.71±6.65

WT: wild type mice; cKO: osteoblast/osteocyte conditional Gja1 knockout mice

^*significant effect of treatment (two way ANOVA);

^ap < 0.05 vs. cKO Saline;

^bp < 0.05 vs. WT Saline;

^cp < 0.05 vs WT BtxA