Table 3.

Changes in Trabecular Number (percent of baseline) in BtxA or Saline Injected Limbs Relative to Non-Injected Control Limbs

Weeks since Injection	3	7	11	15	19
WT Saline	1.51±3.55	2.49±3.89	1.91±3.21	2.68±3.32	1.75±4.18
WT BtxA*	−5.83±5.48	−5.45±5.69	−13.45±4.86b	−7.42±3.77b	−1.33±2.68
cKO Saline	−1.01±7.88	1.98±5.89	−0.75±6.31	1.60±3.72	1.40±10.69
cKO BtxA*	0.73±4.87	−9.36±3.10	−7.95±4.66	−4.98±4.99a	0.01±3.95

WT: wild type mice; cKO: osteoblast/osteocyte conditional Gja1 knockout mice

^*significant effect of treatment (two way ANOVA);

^ap < 0.05 vs. cKO Saline;

^bp < 0.05 vs. WT Saline.